This article considers how the European Union (EU), as the most developed regional organization and as one of the strongest global economic players, deals with the global summitry of club-like entities such as the Group of 20 (G20) and the BRICS grouping of Brazil, Russia, India, China and South Africa. The EU, the G20 and the BRICS share similar ambitions, namely addressing global (or regional) cross-border challenges by increasing cooperation and coordination at the international level.  Even though the EU is a fond supporter of global decision-making bodies, the rise of these informal bodies challenges the EU’s approach to global governance, which relies heavily on effective multilateralism supported by a rules-based approach. Because several of the BRICS and G20 members favour a more relationship-based approach focused on consensus and coordination, these bodies challenge the European approach. While a clear European strategy to deal with informal bodies is thus needed, a coherent and consistent approach is missing.  This is evidenced by the lack of any reference to the BRICS and only a cursory reference to the G20 in the EU’s 2016 global strategy, and by the fact that the EU currently has only bilateral strategic partnerships with most of the G20 and BRICS members. This article argues that, given the particular challenges these bodies pose and their remarkable rise in recent years, a fully fledged EU strategy towards the G20 and the BRICS should be developed.