In this article, the Group of 20’s (G20) networked pluralism and transversal policy practices in the governance of COVID-19 and the pandemic crisis effect are analyzed. The G20 is an important global governance hub, with the strategic capacities and authority to improve cooperation on the pandemic and economic recovery efforts. The forum’s increasingly pluralistic networked-governance processes have been crucial for recent shifts in global governance practices and authority. They were augmented by transversal consequences of the pandemic crisis effect, the latter denoting the consequences of new evidence during a crisis leading to a heightened perception of uncertainty and the repoliticization of background knowledge. The analysis combines a “practice-relational” social constructivist analytical approach with discourse-analytic and sociological insights. It integrates empirical evidence from semi-structured interviews, informal discussions, participant observation, and documentary analysis of G20 engagement on transversal policy dimensions of the COVID-19 pandemic, especially with its interlocutors and governance networks. This indicates the growing significance of networked G20 governance, involving engagement with increasingly pluralistic networks of actors from the Global North and Global South.