Based on the premise that each country has a particular way of interpreting and reacting to international events, the study of strategic culture provides an important analytical tool for understanding and explaining how countries see the world and what drives their foreign policy practices and preferences. Considering that the rise of emerging powers has the potential to affect the balance of power in the international system, this article examines and compares the strategic culture of two of the most important emerging countries in the world, Brazil and India. While apparently exhibiting completely different patterns of strategic thinking, which have led them to pursue different approaches to reach their objectives, these two states share a belief that they are predestined to “greatness,” to play a more significant role in their regional contexts, and to become major stakeholders in global affairs. As the largest countries in their respective regions, Brazil and India can help to shape the future of Latin America and South Asia. Their international behaviour can not only condition the foreign, security and domestic policies and strategies of their neighbours but also impact the ambitions of extra-regional powers with a stake in those regions. Analyzing the strategic culture of these two countries can therefore help policymakers and scholars to understand the rationale for their perceptions and ambitions, what influences and drives their foreign and security policies, how they see the world and why they behave the way they do.