The article outlines the similarities and differences between the two most powerful organizations in the Asia-Pacific region – ASEAN and APEC. It then examines the origins of these structures, contemporary state and future directions of its evolution. This study argues that it is in the interests of participants to keep both organizations to pursue their own national priority. In general we can say that ASEAN has been more effective structure than APEC. This is evidenced by at least the fact that ASEAN is the center of such intergovernmental organizations as ASEAN+3 and East Asian Summit. But ASEAN and APEC in fact are not competing because they were created for different purposes and under the influence of various factors. Thus, ASEAN countries need in APEC, as well as members of APEC are interested in maintaining ASEAN. Despite the prospects and APEC interest of Russian economy, Asian investors still do not recognize Russia as a promising investment land. Thus, Russia faces a major task to develop the concept of optimal interaction with regional integration organizations. Active participation in APEC activities and cooperation with ASEAN give great economic and political importance for Russian geostrategic status as the largest Eurasian power and the grow role of Russian foreign economic relations.