The chapter focuses on the analysis ofSouth Africachanges in health policies due to its transition from the administration of President Thabo Meki to that of Jacob Zuma. The author demonstrates that the focus of attention has shifted from active foreign policy to solving domestic problems such as fighting HIV and AIDS pandemic. However,South Africais seen as a potential continental leader on resolving global health problems and establishing dialogue with African countries and other developing countries in the framework of international organizations and on par with the world leaders.  The paper also describes current trends in cooperation between donors and recipient countries.South Africais one of the first recipient countries that starts achieving self-sufficiency and mutually beneficial cooperation with international partners.